Vaccine type combination study

I've just been looking at https://bepartofresearch.nihr.ac.uk/vaccine-studies/approved-vaccine-studies/ for details of the research project looking at the effects of combining the Pfizer and AstraZeneca vaccines. They're currently looking for volunteer subjects age 50 or over. The London centres involved are UCH and St Georges, Tooting. They want people who haven't had any dose at all yet. They'll be giving two doses, of either the same or different vaccines, at an interval of 4 or 12 weeks. Both those choices will be made randomly, and without informing the subjects of the vaccines used until the end of the study, which lasts a year. More at the above link.

Ianr

Thank you for this post. I have shared it with many people and has hopefully given some of us a way to contribute. I personally have been feeling such a spare part recently.

I was tempted by it, but then found the understandable bar on those who've already had one jab -- it would presumably clash with their protocol and potentially mess up any randomisation. I thought it would be useful to pass on, to save anyone else from spending too much time before reaching that dead end, and in case it was of use to those in lower priority groups. Though I did leave them to discover that there are also small possible 'costs' involved, like the several follow-up tests.

I'm quite open so far to having a mix-and-match imposed on me whenever the second jab is offered, based on the vagueish preconception that there are benefits in heterogeneity. OTOH, perhaps I've been over-influenced by such as Tim Spector's advice to eat 30 varieties of plant each week. Who knows?

ianr Wrote:

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> perhaps I've

> been over-influenced by such as Tim Spector's

> advice to eat 30 varieties of plant each week.

> Who knows?

Do you have a link to that? That's interesting!

ianr Wrote:

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> I've just been looking at

> https://bepartofresearch.nihr.ac.uk/vaccine-studie

> s/approved-vaccine-studies/ for details of the

> research project looking at the effects of

> combining the Pfizer and AstraZeneca vaccines.

> They're currently looking for volunteer subjects

> age 50 or over. The London centres involved are

> UCH and St Georges, Tooting. They want people who

> haven't had any dose at all yet. They'll be

> giving two doses, of either the same or different

> vaccines, at an interval of 4 or 12 weeks. Both

> those choices will be made randomly, and without

> informing the subjects of the vaccines used until

> the end of the study, which lasts a year. More at

> the above link.

A vaccine that hasn't been long term tested, One that hasn't been tested against allergies, One that hasn't been tested in pregnant women? One That doesn't stop you from catching the virus? One that doesn't stop you from transmitting the virus? I wonder why anybody would ever think it may actually be a waste of time or even dangerous to those who take it ? Only 45000 Adverse reactions reported so far in the UK so should be fine https://www.gov.uk/government/publications/coronavirus-covid-19-vaccine-adverse-reactions

to Uplandrd2020

For adverse re-action read mild side effects. A sore arm and a headache would seem more than acceptable.

"Doesn't stop you from catching the virus" Could you quote your proofs.

Peckhampam Wrote:

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> to Uplandrd2020

>

> For adverse re-action read mild side effects. A

> sore arm and a headache would seem more than

> acceptable.

> "Doesn't stop you from catching the virus" Could

> you quote your proofs.

Most sites say Covid vaccine just reduces Symptoms, https://www.fredhutch.org/en/news/center-news/2020/12/covid-19-vaccines-transmission.html

Your site says clearly that the vaccines stop people getting ill but that it is not yet known if they stop transmission. Stopping people getting ill is what we want from a vaccine. If you want to peddle misinformation you seriously will have to do better than this. Up your game uplands.

There's a new second study, COM-COV2 https://comcovstudy.org.uk/participate, which is looking for those aged 50+ who've so far had just one AstraZeneca or Pfizer vaccination between 25th January 2021 and 20th March 2021. Participants will be randomly given either the same vaccine or one of the new Novavax or Moderna vaccines. There'll be blood sampling sessions over a ten month period to test your immune response. There are now three London centres. They say "We are enrolling from all ethnicities and would particularly welcome participants from the Black, Asian and Minority Ethnic (BAME) community."

I'm ruled out of this one too, having had both shots.

I'd have been up for that, but I've had both mine too.