You will not find anything "middle" in the lower east side...it is a recently gentrified (but still edgy) area and will have high end (rivington hotel - v. v. nice and cool), or, incredibly dodgy. For the most part, most of lower manhattan (chelsea, soho, tribeca, nolita, etc) will be high, or, low hotel-wise. You will find mid-priced hotels in midtown (that makes more sense than it should...). There is the W hotel near 14th street that is decent, and, a bit less than the others downtown...and it is in a pretty well-located spot for transport and walking. I'm an ex-new yorker and I'd recommend a walk over the brooklyn bridge, chinatown, ps1 museum, candy at dean and deluca (broadway and prince st), walkers bar in tribeca (good food and drink - not expensive)... enjoy your travels, otto